The computational models shown here (i.e., DeepBE and DeepCas9variants) were generated based on the measured activities of these base editors and Cas9 variants when HEK293T cells were transduced with a lentiviral vector that expresses a base editor or Cas9 variant at a multiplicity of infection of 0.15, so that almost every transduced cell had only one copy of the Cas9 or base editor variant-encoding sequence. Western blotting showed that the levels of most, but not all, Cas9 and base editor variant proteins were comparable. For more information, click here.

Enter target sequences in FASTA format *(sequence length >= 30).

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