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DeepBaseEditor designs optimized guide RNAs for Adenine Base Editors (ABEs) and Cytosine Base Editors (CBEs), predicting their efficiency and outcome proportions.
Base Editors act like "molecular pencils." They chemically rewrite one specific DNA letter into another without cutting both strands of the DNA double helix (unlike CRISPR–Cas9).
This tool provides two models:
ABE: ABE7.10 guide RNA design to convert A•T base pairs to G•C base pairs (A → G or T → C).
CBE: BE4 guide RNA design to convert C•G base pairs to T•A base pairs (C → T or G → A).
Inputs that specify an edit. An unedited/edited sequence pair, ClinVar ID and COSMIC ID are accepted here as ways of naming the edit you want: the target window is resolved from the variant, and each candidate is reported against the conversion it would have to make. No homology-directed repair (HDR) donor is designed on this workflow — a base editor deaminates within its own activity window and makes no double-strand break for a donor to repair from — so when the requested conversion cannot be reached from that window, the run names the editor, its window and the conversion asked for, instead of returning an empty design.
Note: You might also want to use DeepBE, for a larger variety of base editor guide RNA recommendations and efficiency predictions.
